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Thank you for your interest. Please note, the
purpose of this posting is to recruit for on-going and future positions.About City of HopeCity of Hope, an
innovative biomedical research, treatment and educational institution with over
6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening
diseases and guided by a compassionate, patient-centered philosophy.Founded in 1913 and
headquartered in Duarte, California, City of Hope is a remarkable non-profit
institution, where compassion and advanced care go hand-in-hand with excellence
in clinical and scientific research. City of Hope is a National Cancer
Institute designated Comprehensive Cancer Center and a founding member of the
National Comprehensive Cancer Network, an alliance of the nation’s leading
cancer centers that develops and institutes standards of care for cancer
treatment.Position SummaryThe Beckman Research
Institute of City of Hope is looking for a talented Postdoctoral Fellow to
work in the newly established laboratory of Dr. Srividya Swaminathan in the Department
of Systems Biology, City of Hope. We are focused on understanding the immune
microenvironment surrounding B- and T- lymphoid malignancies. By comparing the
global immune landscape during normal and malignant lymphopoiesis, we will
identify immunotherapies that specifically target malignant lymphocytes. Our
research spans Hematology, Oncology, and Immuno-Oncology. We perform
experiments with transgenic mouse models of lymphoid malignancies, primary
human lymphoid cancer cells, humanized mice, transplantation models to study
interactions between malignant lymphocytes and host immunity, gene editing,
classical molecular and cell biology, and oncogenic signal transduction.Methods that will beextensively utilized but not limited to are:
Immune profiling (flowcytometry, mass cytometry (CyTOF), CIBERSORT)
In vivo assays (mouse genetics,immune cell isolation from mice, intravenous and intrafemoraltransplantation assays, humanized mouse models of lymphoma, pre-clinicaltesting of cell-based and other immunotherapies in xenotransplantationmodels, bioluminescence imaging)
Processing and analysis ofhuman leukemia/lymphoma samples and patient-derived xenografts
Molecular biology andbiochemistry (retroviral/lentiviral transduction, molecular cloning, RNA/DNAsequencing, qPCR, immunoblotting, immunofluorescence, luminex)
Recent work:While working as a
Postdoctoral Fellow and then as an Instructor at Stanford University, Dr.
Swaminathan investigated how oncogenes modulate anti-tumor immune surveillance
(Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018 ( https://www.biorxiv.org/content/10.1101/503086v1 ); JITC, 2018 ( https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0431-x ). Using CyTOF in a primary mouse model of
MYC-driven T cell neoplasia, she mechanistically demonstrated the direct and
reversible suppression of natural killer (NK) cells by the MYC oncogene. Her
studies provide a strong rationale for developing NK cells as a therapy against
MYC-driven, and other oncogene-driven lymphoid malignancies that rely on MYC
(Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018 ( https://www.biorxiv.org/content/10.1101/503086v1 ). Dr. Swaminathan’s laboratory will utilize her
extensive research experience in normal and malignant lymphocyte biology
(Nature Immunology, 2015 ( https://www.nature.com/articles/ni.3160 ); Nature Medicine, 2013 ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954721/ ), in identifying the vulnerabilities specific
to malignant lymphocytes. Her laboratory is funded by the Leukemia and Lymphoma
Society (LLS) ( https://www.lls.org/content/induction-of-immunological-memory-to-target-myc-driven-lymphomas ), the American Society of Hematology (ASH) ( https://www.hematology.org/Awards/Award-Recipients/2119.aspx ), and City of Hope.Basic education,experience and skills required for consideration:
A Ph.D. or MD-PhD in life orbiomedical sciences, or a related discipline is required;
Enthusiasm for science, andwillingness to think beyond established concepts;
Experience with flow cytometry,and prior experience with handling mice and performing in vivo procedures;
Enthusiasm to learn newexperimental and computational data analysis tools;
Highly independent withexcellent organizational skills;
Collaborative team player.
Preferred education,experience and skills:
PhD or MD-PhD in Immunology orCancer Biology;
Experience with conductingimmuno-oncology research (preferred).
Additional information:
Please submit your applicationto Dr. Swaminathan via email at sswaminathan@coh.org
Please include with yourapplication a Curriculum Vitae and coordinates of three scientificmentors, and a cover letter highlighting your research interests, a briefstatement explaining how your past research ties in with the goals of ourlaboratory, and future career plans;
For more information, pleasevisit the Swaminathan Lab here: https://www.cityofhope.org/research/systems-biology/systems-biology-research-labs/srividya-swaminathan-lab .
City of Hope is
committed to creating a diverse environment and is proud to be an equal
opportunity employer. All qualified applicants will receive consideration
for employment without regard to race, religion, color, national origin, sex,
sexual orientation, gender identity, age, status as a protected veteran, or
status as a qualified individual with disability.Job: Post-doctoral ResearchTitle: Postdoctoral Fellow - Cancer ImmunologyLocation: California-MonroviaRequisition ID: 10004203