Postdoctoral Fellow - Cancer Immunology

Postdoctoral Fellow - Cancer Immunology

19 Sep 2024
California, Monrovia 00000 Monrovia USA

Postdoctoral Fellow - Cancer Immunology

Vacancy expired!

Thank you for your interest. Please note, the

purpose of this posting is to recruit for on-going and future positions.About City of HopeCity of Hope, an

innovative biomedical research, treatment and educational institution with over

6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening

diseases and guided by a compassionate, patient-centered philosophy.Founded in 1913 and

headquartered in Duarte, California, City of Hope is a remarkable non-profit

institution, where compassion and advanced care go hand-in-hand with excellence

in clinical and scientific research. City of Hope is a National Cancer

Institute designated Comprehensive Cancer Center and a founding member of the

National Comprehensive Cancer Network, an alliance of the nation’s leading

cancer centers that develops and institutes standards of care for cancer

treatment.Position SummaryThe Beckman Research

Institute of City of Hope is looking for a talented Postdoctoral Fellow to

work in the newly established laboratory of Dr. Srividya Swaminathan in the Department

of Systems Biology, City of Hope. We are focused on understanding the immune

microenvironment surrounding B- and T- lymphoid malignancies. By comparing the

global immune landscape during normal and malignant lymphopoiesis, we will

identify immunotherapies that specifically target malignant lymphocytes. Our

research spans Hematology, Oncology, and Immuno-Oncology. We perform

experiments with transgenic mouse models of lymphoid malignancies, primary

human lymphoid cancer cells, humanized mice, transplantation models to study

interactions between malignant lymphocytes and host immunity, gene editing,

classical molecular and cell biology, and oncogenic signal transduction.Methods that will beextensively utilized but not limited to are:

Immune profiling (flowcytometry, mass cytometry (CyTOF), CIBERSORT)

In vivo assays (mouse genetics,immune cell isolation from mice, intravenous and intrafemoraltransplantation assays, humanized mouse models of lymphoma, pre-clinicaltesting of cell-based and other immunotherapies in xenotransplantationmodels, bioluminescence imaging)

Processing and analysis ofhuman leukemia/lymphoma samples and patient-derived xenografts

Molecular biology andbiochemistry (retroviral/lentiviral transduction, molecular cloning, RNA/DNAsequencing, qPCR, immunoblotting, immunofluorescence, luminex)

Recent work:While working as a

Postdoctoral Fellow and then as an Instructor at Stanford University, Dr.

Swaminathan investigated how oncogenes modulate anti-tumor immune surveillance

(Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018 ( https://www.biorxiv.org/content/10.1101/503086v1 ); JITC, 2018 ( https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0431-x ). Using CyTOF in a primary mouse model of

MYC-driven T cell neoplasia, she mechanistically demonstrated the direct and

reversible suppression of natural killer (NK) cells by the MYC oncogene. Her

studies provide a strong rationale for developing NK cells as a therapy against

MYC-driven, and other oncogene-driven lymphoid malignancies that rely on MYC

(Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018 ( https://www.biorxiv.org/content/10.1101/503086v1 ). Dr. Swaminathan’s laboratory will utilize her

extensive research experience in normal and malignant lymphocyte biology

(Nature Immunology, 2015 ( https://www.nature.com/articles/ni.3160 ); Nature Medicine, 2013 ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954721/ ), in identifying the vulnerabilities specific

to malignant lymphocytes. Her laboratory is funded by the Leukemia and Lymphoma

Society (LLS) ( https://www.lls.org/content/induction-of-immunological-memory-to-target-myc-driven-lymphomas ), the American Society of Hematology (ASH) ( https://www.hematology.org/Awards/Award-Recipients/2119.aspx ), and City of Hope.Basic education,experience and skills required for consideration:

A Ph.D. or MD-PhD in life orbiomedical sciences, or a related discipline is required;

Enthusiasm for science, andwillingness to think beyond established concepts;

Experience with flow cytometry,and prior experience with handling mice and performing in vivo procedures;

Enthusiasm to learn newexperimental and computational data analysis tools;

Highly independent withexcellent organizational skills;

Collaborative team player.

Preferred education,experience and skills:

PhD or MD-PhD in Immunology orCancer Biology;

Experience with conductingimmuno-oncology research (preferred).

Additional information:

Please submit your applicationto Dr. Swaminathan via email at sswaminathan@coh.org

Please include with yourapplication a Curriculum Vitae and coordinates of three scientificmentors, and a cover letter highlighting your research interests, a briefstatement explaining how your past research ties in with the goals of ourlaboratory, and future career plans;

For more information, pleasevisit the Swaminathan Lab here: https://www.cityofhope.org/research/systems-biology/systems-biology-research-labs/srividya-swaminathan-lab .

City of Hope is

committed to creating a diverse environment and is proud to be an equal

opportunity employer. All qualified applicants will receive consideration

for employment without regard to race, religion, color, national origin, sex,

sexual orientation, gender identity, age, status as a protected veteran, or

status as a qualified individual with disability.Job: Post-doctoral ResearchTitle: Postdoctoral Fellow - Cancer ImmunologyLocation: California-MonroviaRequisition ID: 10004203

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