Vacancy expired!
Research Associate, San Diego, CASummary/Scope: The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of novel cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.Job Duties and Responsibilities:
Utilize RNAi and CRISPR to determine the disease relevance of novel therapeutic targets
Explore the structural and activity relationship (SAR) of small drug inhibitors using various cell based assays including western, RT-PCR, immunofluorescent staining, and flow cytometry.
Define the MOA of candidate agents using hypothesis-driven approach as well as unbiased genome-wide CRISPR screen
Design and develop novel assays
Document, interpret and troubleshoot results
Convey data analysis and interpretation to supervisor and colleagues
Communicate with peers and supervisors and foster teamwork
Contribute to collaborative efforts
Strong commitment to quality and reproducibility
Demonstrate adaptability
Supervise or guide research staff
Other duties as assigned.
Job Requirements:
Master's degree (MS) and one (1) to two (2) years of relevant, industry experience.
Extensive wet-lab experience with routine molecular, cellular and genetic biology tools
Highly motivated and strong team player with a high degree of independence
Innovative and critical thinking
Excellent time management and organizational skills
Strong communication skills, both written and oral
For immediate consideration, apply today! Questions? Call 858.207.6311Why Kelly ® ?With Kelly, you’ll have access to some of the world’s highest-regarded scientific organizations—providing you with opportunities to work on today’s most challenging, research-intensive, and relevant projects. Our connections can lead you to innovative scientific pursuits you’ll be proud to help advance. We work with 95 of the Fortune 100™ companies, and found opportunities for more than 9,000 scientific professionals last year.You pursued a career in science to fuel your quest for knowledge and your desire to make the world a better place. Let Kelly fuel your career—connect with us today.AboutKelly Services ®As a workforce advocate for over 70 years, we are proud to directly employ nearly 500,000 people around the world and have a role in connecting thousands more with work through our global network of talent suppliers and partners. Revenue in 2017 was $5.4 billion. Visit kellyservices.com and connect with us on Facebook , LinkedIn and Twitter .Kelly Services is an equal opportunity employer including, but not limited to, Minorities, Females, Individuals with Disabilities, Protected Veterans, Sexual Orientation, Gender Identity and is committed to employing a diverse workforce. Equal Employment Opportunity is The Law.
