My client is a rapidly expanding biotech company developing the latest generation of T Cell Immunotherapies. They are currently looking for experienced Scientific Leader to head up their Protein Engineering function.
Responsibilities
Supervision of up to 9 RA and Scientists, leading collaborations for TCR development
Development of internal platforms, based on affinity maturation of TCRs
Protein engineering support for lead TCRs identified for T cell therapies with the goal to generate compounds with optimal therapeutic indexes (optimal efficacy and safety characteristics).
Development of TCR libraries for rapid TCR lead optimization and selection. Continuous optimization of display libraries, library diversity and composition
Biophysical characterization of lead compounds
Contributions to regulatory filings of biotherapeutics
Leading external collaborations as well as interacting with internal and external stakeholders. Regular presentations in front of the board or investors
Skills and Qualifications
5 to 10 years of industry experience working in Molecular Biology, Protein Engineering, Biochemistry or similar.
Track record in leading a protein engineering group and contributions to therapeutic compounds advancing to IND filings, clinical trials.
Engineering of IgGs, VHHs or other scaffolds.
Phage and/or yeast display technology, mammalian library design and screening, high throughput screening of scFvs, VHHs, Biacore, structure guided protein engineering
Interaction with CROs and other research organizations
FACS, T-cell assay development, TCR engineering, strong familiarity with Bioinformatics.
The Benefits
Based in the Bay Area, California – one of the world largest and most exciting Biotech and Tech hubs
Competitive salary and benefits package
Progression opportunities – Chance to get on the ground floor with a well-funded and rapidly expanding Biotech
If you are looking to take the next step in your career in the Biotech industry and you would like to know more about this role or the other opportunities we currently have on our books, please apply now with your CV to speak with our specialist Scientific Consultant William Ashbrook