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378049BR Job ID: 378049BR Job Description: More than 100,000 people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life. The Pharmacokinetic Sciences (PKS) Department within the Novartis Institutes for Biomedical Research (NIBR) in Cambridge, Massachusetts is looking for a laboratory -based biotransformation scientist to join their global biotransformation team (with groups in Europe and North America) to strengthen the department’s metabolite profiling and identification capabilities for new modalities such as antibody drug conjugates, oligonucleotides, or peptides. Additionally, knowledge of small molecule biotransformation would be considered advantageous. As a biotransformation scientist working on new modalities, you will develop state-of-the-art analytical methodologies using high resolution mass spectrometry and be familiar with the chromatography, structure elucidation, and data processing requirements needed to characterize metabolites of intact proteins, oligonucleotides, and peptides. You will plan and execute tailored experiments, maintain the laboratory environment/instruments, and support the development of new technologies. You will also be expected to interact with and present your findings in team meetings, document your findings, and prepare internal reports. As the successful candidate you will be adaptable, independently motivated, and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand ADME properties, metabolite identification, biotransformation pathways, and routes of elimination for a diverse portfolio of therapeutic modalities. Therefore, the ideal candidate should have a good understanding of the drug discovery/development process and have a keen interest in implementing/optimizing new experimental methods for the analysis of new modalities. Furthermore, depending on the seniority of the successful candidate, you will represent the ADME line function in PKS sub-teams and project teams, collaborate in the preparation of external publications, and contribute to registration documents. Your main accountabilities will include: Design and execution of biotransformation studies to assess metabolic pathways and structural elucidation of metabolites Organize and prepare experimental protocols and study reports with upload of results to a centralized database Presentation of key findings to project teams and/or other stakeholders Support discovery, pre-clinical, and clinical development studies (in vitro and in vivo) to aid drug candidate progression Assure quality standard guidelines and safe work practices are applied while working in the laboratories This position will be located at our Cambridge, MA site and will not have the ability to be located remotely. Posting Title: Senior Scientist, Biotransformation PK Sciences Minimum requirements: What you will bring to the role: Minimum requirements Degree in Chemistry/Biochemistry/Biology/Pharmaceutical Sciences with experience in drug discovery/development, or a higher degree with research experience relevant to drug metabolism or mass spectrometry science PhD with 0 years, MS with 3+ years, or BS with 8+ years of relevant experience Title and salary will be commensurate with experience The ideal candidate will draw from any the following key skillsets: Hands-on experience in operation, maintenance, and troubleshooting of state-of-the-art high resolution mass spectrometers Prior experience with immunoprecipitation, intact protein, peptide, and/or oligonucleotide analysis (small molecule biotransformation knowledge also desirable) Familiarity with in vitro systems commonly used for drug metabolism studies (hepatocytes, homogenate, microsomes, S9 fraction, recombinant enzymes) Experience with reverse phase, ion pairing and size exclusion HPLC/UPLC Excellent oral and written communication skills Careful attention to detail, exceptional organizational skills, and ability to multitask Why Novartis? 736 million lives were touched by Novartis medicines in 2022 and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis! Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. The pay range for this position at commencement of employment is expected to be between $88,000 and $153,600/year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Job Type: Full Time Country: USA Work Location: Cambridge, MA Functional Area: Research & Development Division: Novartis Institutes for BioMedical Research Business Unit: Translational Medicine Employment Type: Regular Company/Legal Entity: NIBRI EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Shift Work: No Early Talent: No
