Job DescriptionPosition Description:Senior Scientist Cell Based Potency VaccinesThe Analytical Research and Development team in West Point, PA is seeking an exceptional scientist who is passionate about innovative science and analytical solutions that enable and accelerate process and product development. The Senior Scientist within the department of Cell Based Sciences will join our vaccines team in West Point, PA.The successful candidate will be responsible for development, of cell-based potency assays to support our Vaccine pipeline with responsibilities including development of new assay platforms and benchmarking current approaches/techniques to the industry standards.The primary role of the candidate will be method development, optimization, and transfer of cell-based assays for drug substance and drug product release, stability, and characterization that reflect the mechanisms of action (MoAs) for our Vaccines pipeline.The candidate will be expected to work independently, communicate results effectively in presentations to stakeholders in partner organizations or at external scientific meetings, to write technical reports, and to participate in cross-functional teams. The individual will enable and accelerate vaccine process development by applying cellular biology and immunology expertise.The ideal candidate should bring expertise in a wide variety of methods and technology for assessment of vaccine mechanism of action and potency with an emphasis on subject matter expertise related to cell based analysis of innate immunity, adaptive immunity, intracellular and secreted cytokines/chemokines/effectors, activation, proliferation, and differentiation of myeloid and lymphoid cells.Position Qualifications:Education Minimum Requirements:
B.S degree with 6+ years of experience,
M.S. degree with 4+ years of experience or
Ph.D. degree in immunology, virology, microbiology, biochemistry, cell biology, bioengineering, biological sciences, or related field with experience in the biopharmaceutical industry.
Required Experience and Skills:
Experience working on vaccine research and/or development.
Experience working with mammalian cell lines and BSL2 level biological agents.
Scientific and technical expertise in cellular immunology and humoral / cell-mediated responses to vaccines.
Expertise in developing cell based potency assays to reflect mechanism of action of drug candidates.
Experience with immunological assays such as ELISA, Western blot, flow cytometry-based assays, etc.
A strong team player with excellent oral and written communication skills; ability to work independently.
Ability to deliver complex objectives in a fast paced environment.
Preferred Experience and Skills:
Prior experience in bringing and applying new technologies suitable for bioassay development such as cell line engineering, stable clone generation, cell banking and cell imaging.
Experience establishing the range, accuracy, intermediate precision, and repeatability of an assay.
Working knowledge in utilizing statistical approaches such as design of experiments (DoE) in developing potency assays to identify sources of assay variability, developing operating ranges within an assay procedure that keep assay variability at a minimum.
Working experience in a regulated environment, following standard operating procedures (SOPs), real-time documentation of experimental work, and attention to detail.
Proficiency in utilizing statistical software such as JMP, curve-fitting software such as PLA, SoftMax Pro, or GraphPad Prism, and data trending software such as Spotfire.
Experience with automation of assays
Working knowledge of regulatory and industry guidelines for Chemistry Manufacturing and Controls (CMC).
#EligibleForERPCurrent Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088EEOCKnowYourRights1020.pdf)EEOC GINA SupplementPay Transparency Nondiscrimination (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp%20EnglishformattedESQA508c.pdf)We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)U.S. Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance OrdinanceLos Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring OrdinanceSearch Firm Representatives Please Read CarefullyMerck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.Employee Status:RegularRelocation:DomesticVISA Sponsorship:YesTravel Requirements:10%Flexible Work Arrangements:Not ApplicableShift:Not IndicatedValid Driving License:NoHazardous Material(s):BSL-2, OEBJob Posting End Date:12/2/2024A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.Requisition ID: R324580
