ROLE SUMMARYPfizer ORU (Oncology Research Unit) is seeking a highly capable, enthusiastic and motivated Scientist to join the Protein Solutions team. The Protein Solutions team is an integral part of Protein and Bioanalytical Sciences (PBS) group within ORU ADC Discovery. This multidisciplinary team is at the forefront of producing recombinant proteins and antibodies for the development of antibody-drug conjugates (ADCs) and this scientist will play a critical role in supporting the preclinical efforts in developing novel ADC therapeutics.KEY RESPONSIBILITIES
Strong focus on integration and optimization of reagent (DNA & Protein) registration and inventory systems
Development of tools and applications to facilitate requests and support queue efficiencies
Collaboration with scientists to generate protein reagents to support research projects
DNA sequence design, vector construction, & nanopore sequencing
Production of recombinant proteins (including antigens, antibodies, bi-specifics, fusion proteins and small format binders) via mammalian expression and affinity purification
Analytical and functional characterization of purified products
Independent design and optimization of experiments
Data analysis, report generation and presentation of results; including technical reports, patent documentation and tracking of reagents and requests
Mentor/teach standard practices for protein production and characterization to lab colleagues
BASIC QUALIFICATIONS
M.S. plus 4 or B.S. plus 6 years' experience; both with 2 of those years in the biopharmaceutical industry; or related discipline
Demonstrated experience with using, building and optimizing registration and request workflows
Proficient in recombinant protein expression via mammalian cells and protein purification using liquid chromatography techniques
Expertise in molecular biology techniques; including design, PCR, mutagenesis, subcloning, and sequence analysis
Experience in evaluating protein product quality; including, analytical chromatography and mass spectrometry
Ability to perform routine tasks independently and commitment to high quality analysis and documentation
Team player with a strong record in collaboration and excellent written/oral communication skills
Detail-oriented with strong analytical, organizational, and multi-tasking skills
Flexibility and prioritization skills to meet personal and group goals
PREFERRED QUALIFICATIONS
Design and implementation of novel fusion, small-format and bispecific methods and technologies
Knowledge of antibody sequence structure, germlines, isotype, alleles and common variants to modify Fc function.
Understanding of cancer biology and experience with oncology drug development
Familiarity with developability and biophysical characterization assays
Experience with high throughput and automated lab equipment and assays
Additional Information:
Work Location- On Premise
Last Day to Apply: January 1, 2025
The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.Research and Development
