The Lab Service Technician II is responsible for delivering assigned sequencing and probe projects on time and to quality control (QC) and client standards. This role will follow designated work instructions and operating procedures to effectively design, synthesize, and validate probes and libraries for a variety of technical workflows, including whole-genome (WGS), skim, Flex-seq, and Capture-seq. Due to the custom nature of these projects, the Lab Technician II must be able to partner effectively with other operational functions to achieve designated project goals and deliverables. To perform this job successfully, an individual must be able to perform each of the following essential functions satisfactorily: In collaboration with Project Management, perform sample processing that meets the demands of designated project goalsLog samples to LIMS and other IT infrastructure, update databases to ensure effective tracking of sample processingPartner with the Extraction team to ensure effective delivery of extracted material; extract DNA from, and perform QC processes on, samples where requiredEnsure that DNA is of a size and concentration suitable for library preparation and bring together projects using appropriate methods (e.g. shearing, segmentation)Build barcoded libraries for assigned technical workflows, using a variety of methods such as end-repair/A-tailing and tagmentationPrepare pools, including consolidation of prepared libraries and verification of pool qualitySynthesize and perform quality control processes on new probe panels, including validation of their effectiveness, for various technical workflowsUse customized probes to perform designated operational processes on librariesPropose improvements to processes and operations resulting in optimized project outcomes; implement process improvements as approved by functional management Partner with Project Management and designated Process Leads to ensure appropriate prioritization of sample processing and sequencingStore client DNA and libraries in an organized and rational mannerContribute to an effective, safe, and clean lab environment through various support activitiesContribute to the development of best practices and process improvementsPerform other duties as required or requested to meet business needs
