Key Responsibilities:We are seeking a scientific contributor to lead and execute novel LNP formulation process development activity for the delivery of circular RNA therapeutic at scale. This role will spearhead LNP process development/scale up activity and would be responsible for designing and executing DOE-based formulation process optimization. They would engineer and functionalize LNPs, develop analytics for formulation quality control, and develop processes to improve formulation at scale. The candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams, plan and run animal studies with a cross-functional group of scientists, and support the growth and career development of junior scientists. The ideal candidate is a chemical engineer/pharmaceutical major with strong LNP formulation, optimization, and process development experience, who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.Establish, execute and document protocols for preparation and characterization of targeted LNP formulations with nucleic acid cargo for in vitro and in vivo studiesDesign and execute DOE-driven studies for LNP composition, mixing parameters and process optimization to improve formulation quality, stability, delivery efficiency and functional activityDevelop cell and molecular biology assays to assess the delivery efficiency of RNA cargo in mammalian primary cells to facilitate development of therapeutics drugs pipelinesAssist in the buildout of formulation and analytical capabilities with focus on delivery with nanoparticle technology, lyophilization and process development for scale up/productionContribute to patent applications related to the delivery technologySupport technology transfer to CDMOs and Industry PartnersFoster collaborative relationships across the team and company and engage in a positive and exciting work environmentContribute to hiring, training, and collaborating with scientists (as needed) to formulate, characterize, develop, and support assessment of efficacyPlan and coordinate animal studies with in vivo teamAuthor technical documents, including SOPs for formulation processes and analytical methods, maintain diligent records and demonstrate proficiency in scientific communicationSupport high-quality documentations to support regulatory filings
