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Job Description : We are looking for a highly qualified and motivated scientist to join the precision neurology and neuroinflammation cluster, focused on discovering, validating, and developing therapies for rare neurologic and neurodegenerative diseases including Alzheimer’s, Parkinson’s, and ALS. This position is laboratory-based and will include designing and executing experiments to identify and confirm new therapeutic targets, leading project teams, and working effectively with internal and external collaborators to advance ongoing exploratory and portfolio projects. The successful candidate will have a Ph.D. and postdoctoral training in neurodegeneration, glial biology, and/or neuroimmunology either in academia or industry. A passion for drug discovery and expertise in cellular and molecular biology, protein biochemistry, proteomics, transcriptomics, CRISPR, and other approaches to identify and validate targets and pathways.Key Responsibilities:
Develop tools to model neurodegenerative disease and study neuron-glia and glia-glia signaling in vitro using primary rodent and human cell cultures and human iPSC cells.
Validate in vivo mouse and rat models of neurodegeneration to measure target engagement and tease apart disease mechanisms.
Generate transcriptomic, proteomic, and lipidomic datasets to credential pathway targets and generate new leads.
Design and execute experiments, analyze data and clearly communicate results at internal and external meetings and conferences.
Interact in a matrixed, dynamic and cross-functional manner across the Rare and Neuroscience Therapeutic Area, Research Platforms, and external collaborators.
Establish and maintain a scientific network external to the company to advance portfolio projects through collaborations, licensing opportunities and business development.
Help guide new drug candidates from the early exploratory discovery stage to the clinic.
Qualifications, Competencies and Characteristics:
Ph.D. in neuroscience, neurodegeneration, neuroimmunology, or related field with >2 years of postdoctoral training or M.S. with 6 years of industry experience.
Expertise in neurodegenerative and neuroinflammatory disease and experience with cell- and animal-based disease models.
Outstanding track record of publications in neurodegenerative disease, neuroimmunology, immunology, and/or related areas.
Extensive experience with both in vivo and in vitro models and tools preferred.
Understanding of in vivo pharmacology and/or molecule biodistribution in rodents or NHPs.
Knowledge of ASO or siRNA screening approaches.
Ability to work collaboratively to identify and execute key steps necessary to advance projects in a time- and resource-sparing fashion.
Ability to effectively develop and discuss experimental goals and research progress with scientists and stakeholders of varied backgrounds.
Excellent analytical, presentation and writing skills.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.#GD-SA#LI-SAPDNAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
