About the Job We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?Job Description: The Immune Checkpoint Cluster, within the Immunology & Inflammation Therapeutic Area in Sanofi, aims to discover new mechanistic pathways in autoimmune diseases and to develop these findings into novel disease-modifying drugs that improve the lives of patients. Our focus is on inflammatory processes mediated by dysregulated innate and adaptive immunity, resulting in loss of immunological tolerance. Disease areas of interest reflect these mechanisms and include systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and Type 1 Diabetes (T1D) and may extend into other immune-mediated pathologies according to where our scientific discoveries lead us. We wish to recruit a Scientist 1 who will work in a dynamic, matrix laboratory team environment, with the aim to identify new disease targets and transition these through to drug development. The successful candidate should have a solid background in immunology and the demonstrated ability to productively integrate into research projects as part of a collaborative team, contributing both technical expertise and functional knowledge. Competitive applicants with hands-on experience in cytokine signaling, innate sensing pathways and/or regulatory T-cell (Treg) biology are strongly encouraged to apply. S/he should be able to work with a high degree of flexibility and under limited supervision, managing time efficiently to enable contribution to multiple projects simultaneously. Job Responsibilities:
Contribute to and/or lead drug discovery programs through design and execution of experiments to evaluate the efficacy and safety of therapies targeting cytokines, innate sensors, and checkpoint receptors for autoimmune disease intervention. This will involve both in vitro and in vivo experimentation, as well as data collection and analysis.
Provide oral and written communication of project updates and data packages to varied audiences.
Maintain awareness of current scientific developments in the autoimmunity field and integrate this knowledge to improve/enhance current research activities and to propose and champion new targets for novel therapeutic programs.
Maintain a detailed and timely electronic lab notebook in compliance with Sanofi laboratory guidelines.
Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling and disposal of materials such as active drug substances and biohazardous material.
This position requires significant hands-on laboratory benchwork and has no direct reports.
About you Qualifications:
Ph.D. in immunology or related field with at least 1 year of post-doctoral laboratory experience OR Master’s degree plus >3+ years OR Bachelor’s degree plus >5+ years laboratory experience in an academic or biopharmaceutical setting, preferably including a strong background in immunology.
Significant experience isolating primary mouse and/or human immune cell subsets for subsequent modification and characterization in complex immunological assays.
Working knowledge of high-dimensional flow cytometry and FACS-based immunophenotyping (both panel design and downstream data analysis using FlowJo or similar software).
Proficiency across cellular and molecular techniques, which may include stable (reporter) cell line generation and characterization, protein detection (MSD, Luminex, Jess), and gene profiling (RT-PCR, NanoString, NGS).
S/he must be scientifically rigorous, highly organized, and self-motivated; must be able to work independently while interacting and maintaining strong working relationships across a diverse group of research collaborators.
Demonstrated curiosity and ability to master new skills, troubleshoot both technical and scientific problems, and analyze and interpret experimental data and suggest next steps.
Excellent organizational and time management skills required.
The following would be highly desirable but are not a prerequisite: in vivo mouse experience (live handling, post-mortem tissue acquisition and processing) or the willingness to learn; experience with CRISPR/Cas9 gene editing & lentiviral gene modification technologies.
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.#GD-SA#LI-SA#LI-Onsite#vhdPursue progress , discover extraordinaryBetter is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) !US and Puerto Rico Residents Only Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live.All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)
