Eurofins PSS West is looking for a Principal Formulations Scientist to develop and characterize formulations on complex and poorly behaved drug candidates, advance data management and documentation practices, and partner in the innovative application of AI at a client site in San Diego, CA. This scientist combines hands-on lab skills with data-driven, modeling-based assessment of compounds. They are expected to work independently and act as a technical resource for the team.Responsibilities include, but are not limited to:Design and develop prototype and complex formulations (solutions, suspensions and enabling formulations) for oral, subcutaneous, and/or intravenous (sterile) delivery to support in-vitro and in-vivo studies.Formulate and characterize poorly behaved compounds, including those with low solubility or poor stability, and develop strategies to overcome their limitations.Contribute to compound risk assessments utilizing physicochemical property information, in vivo performance data, and predictive tools.Design and interpret studies of solubility, chemical and physical stability, and in-vitro performance (non-sink dissolution, precipitation).Apply analytical techniques (HPLC, DSC, PXRD, spectroscopy), both conceptually and in the lab, to characterize compounds and formulations.Use physiologically based pharmacokinetic (PBPK) and physiologically based biopharmaceutics modeling (PBBM) tools such as GastroPlus to predict compound and formulation performance.Partner in the novel application of AI in the advancement of new molecules.Curate data from contract research organizations (CROs) and other external partners.Write and review study protocols and technical reports.Record work in an ELN, and help develop ELN standards and best practices.
